Possible bad news about SA variant

Liamo said:
It has a different designation (viral vector as opposed to mRNA) but it works in an almost identical manner.

All three vaccines consist of a lipid membrane, within which is inserted a piece of genetic code with instructions to prompt the ribosomes inside a human cell to produce copies of the SARS-CoV-2 spike protein.

The main difference is in the carrier used to transport the genetic instructions into the human cells.

The Pfizer-BioNTech and Moderna vaccines use a purely artificial lipid membrane designed in a lab whereas the Oxford-AstraZeneca vaccine uses the lipid membrane from a non-replicating adenovirus as the means of carrying the instructions into the body.

Once these different lipid membranes latch onto the human cells and deliver their genetic instructions, the process that then takes place, with the ribosomes reading the instructions and creating the spike proteins, is virtually identical no matter which one of the three vaccines you're talking about.

The human body's reaction to the presence of the coronavirus spike proteins created in this manner should be essentially identical as far as I can tell, whether the instructions to create the spike proteins were carried into the cell by an mRNA or viral vector vaccine.

If I can make an analogy, it's like getting the same model new phone delivered to your house either by a van driver or by a motorbike rider. It doesn't matter how the phone was delivered, it will still work the same once you start using it.
Click to expand...
That's pretty impressive Liamo. Thanks
 
As a picture is worth a thousand words, here's a diagram showing how the Oxford vaccine works.

Replace the words "a harmless virus" with "an artificially-created, virus-like lipid membrane" and the diagram could be captioned, "How the Pfizer (or Moderna) vaccine works."

Screenshot_2021_0126_172538.png
 
I replied to this thread previously but (somewhat gratifyingly) I've just come across a newly-published article where an actual communicable diseases expert makes the same point about the Oxford-AstraZeneca, Pfizer-BioNTech and Moderna vaccines being essentially identical in the way they work (just with a slightly different delivery mechanism).

It's actually talking about combining the different vaccines rather than their efficacy against variants but the underlying principle, that the vaccines deliver the identical genetic code (in a virtually identical manner) and should therefore stimulate the immune system in the same way, is essentially the point I was trying to make.

Dr Peter English, consultant in communicable disease control, pointed out that the antigen used across the currently authorized COVID-19 vaccines is the same Spike protein. Therefore, the immune system can be expected to respond just as well if a different product is used ..
Click to expand...

Study Will Test Combination of Different COVID-19 Vaccines
 
Osboro said:
What's it like being in a 1st World Country?
Lovely place NZ.
Click to expand...

NZ is a very different situation to the UK.

When SARS-CoV-2 was detected in China, and subsequently was detected in Italy, Spain, UK in early 2020 (was actually present in late 2019 in europe) NZ was at the end of summer. The advantage was it is isolated, was in summer (so v little transmission of any cases already present) and was able to shut borders, quarantine etc. Followed WHO pre-2020 guidelines for its own situation. So far so good. A note of caution.....

1612589079152.png

Infection induced immunity in addition to vaccine induced immunity will give better "overall protection".

As usual though people just point to countries that have low deaths (and say "why didn't we do what NZ, AUS, South Korea, Japan etc do") without considering why that might be the case (age distribution of population, geography, climate, obesity).
 
r00fie1 said:
View attachment 13355
Click to expand...

Border controls for a virus which is endemic is pointless (agreed by WHO prior to 2020 madness and by Chris Whitty in public lectures). The virus was in Europe in late 2019 and we had no tests, community transmission was already occurring.

Current border measures are pure political posturing. Yes, lets quarantine travelers who arrive by air but at the same have no quarantine for the hauliers who cross the channel every day.

Do you you really buy this nonsense?
 
T_A_D said:
Border controls for a virus which is endemic is pointless (agreed by WHO prior to 2020 madness and by Chris Whitty in public lectures). The virus was in Europe in late 2019 and we had no tests, community transmission was already occurring.

Current border measures are pure political posturing. Yes, lets quarantine travelers who arrive by air but at the same have no quarantine for the hauliers who cross the channel every day.

Do you you really buy this nonsense?
Click to expand...
I wouldnt be posting a cartoon like that if I did would I?
 
We had the "UK variant" and "South African" variant...... both, we were told, would run wild in the UK.

What has happened to "cases" in the UK and South Africa?............ both have dropped considerably.
 
You must log in or register to reply here.
Back
Top