Coronavirus good news thread

bear66 said:
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Here is the cut and paste of it -

‘Mérida, October 26, 2020 (venezuelanalysis.com) – The Venezuelan Institute for Scientific Investigations (IVIC) has claimed the discovery of a new and highly effective treatment for COVID-19 symptoms.
According to the IVIC, six month trials using a DR-10 antigen have proved it to have a “100 percent effectiveness in neutralising the coronavirus” without causing “toxic side effects.”
The antigen forms part of the Human Leukocyte Antigen – DR isotype and is already used to fight hepatitis C, human papilloma, arthritis, cervical cancer and Ebola.
According to President Nicolas Maduro, who unveiled the breakthrough, the IVIC plans on taking the results to the World Health Organization for “ratification” and “mass production” to contribute towards global anti-pandemic efforts. The antigen is also due to be added to Venezuela’s authorised Covid-19 treatments, which include Remdesivir and ozone therapy.
Venezuela remains one of the Latin American countries least-affected by the coronavirus pandemic. On Sunday, 423 new cases were identified, continuing the downward trend since daily cases peaked around 1200 last month. Authorities have already signed commercial deals with Russian- and Chinese- produced vaccines currently undergoing clinical trials, and government spokespersons have claimed to have “definitely flattened the curve.”
Authorities have recently authorised a further opening up of sectors of the economy, allowing tourist attractions, hotels, tour agencies and national parks to open on a week-on-week-off basis.’
 
Not good news yet, but definitely one to watch, given several outfits are progressing trials with this drug, using different delivery methods. Could this tapeworm treatment be the drug we’ve all been waiting for? Fingers crossed for positive and speedy trial results-

In an animal study - ‘40% of the placebo-treated subjects died, both the preventive and therapeutic treatment groups injected with DWRX2003 12 hours before or 7 days after the infection resulted in FULL SURVIVABILITY.’

‘Niclosamide is a potent inhibitor of SARS-CoV-2 with potency >40x higher than remdesivir as demonstrated by Institut Pasteur Korea’

https://www.pharmaceutical-technology.com/news/ana-therapeutics-niclosamide-covid/

https://www.prnewswire.co.uk/news-r...ective-against-influenza-virus-820794242.html

https://www.biospace.com/article/re...d-19-with-intranasal-delivery-of-niclosamide/
 
FabioPorkpie said:
Good (Although not unexpected) news regarding T cell immunity indications -

https://uk.reuters.com/article/instant-article/idUKKBN27I1LL
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Slightly more detailed article about the same study.

T-Cell Responses to SARS-CoV-2 Still Present Six Months After Initial Infection

Bottom line:
This is an important manuscript, building on a number of published studies that demonstrate T-cell responses to SARS-CoV2 and showing that T-cell responses occur even following mild or asymptomatic infections and persist for at least six months. These findings increase confidence that SARS-CoV2 infection can induce robust T cell immunity, at least in this relatively young, mild/asymptomatic disease cohort, and that this immunity persists even when antibody levels are falling.
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New nanoparticle vaccine candidate designed by computer shows promise:
Compared to vaccination with the soluble SARS-CoV-2 Spike protein, which is what many leading COVID-19 vaccine candidates are based on, the new nanoparticle vaccine produced ten times more neutralizing antibodies in mice, even at a six-fold lower vaccine dose.

The data also show a strong B-cell response after immunization, which can be critical for immune memory and a durable vaccine effect. When administered to a single nonhuman primate, the nanoparticle vaccine produced neutralizing antibodies targeting multiple different sites on the Spike protein. Researchers say this may ensure protection against mutated strains of the virus, should they arise.
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The study in question is not yet peer reviewed, but it points to the immune response behaving better when it comes to re-exposure -

https://www.theguardian.com/world/2...ger-post-infection-coronavirus-scientists-say

“This is good news for everybody who has been sick with coronavirus.” He said the immune system was like an army that stands down once the threat is over, but remains prepared for a future invasion. “You want the army to be generated again very quickly, and this is what these researchers have found.”
 
Exciting news from a study that found cross reactivity between common cold antibodies and SARS COV2, particularly in children.
More research to do but potentially very positive news -

“This is exciting as understanding the basis for this activity could lead to vaccines that work against a range of coronaviruses, including the common cold strains, as well as SARS-CoV-2 and any future pandemic strains.”

https://www.crick.ac.uk/news/2020-1...r&utm_medium=social&utm_campaign=SocialSignIn
 
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It would be pretty cool if they accidentally eradicated the common cold, at the same time as finding a Covid19 vaccine :ROFLMAO:

I get a cold every bloody winter!
 
Cuthbert said:
It would be pretty cool if they accidentally eradicated the common cold, at the same time as finding a Covid19 vaccine :ROFLMAO:

I get a cold every bloody winter!
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Not sure you could completely eradicate it as many of the common colds we pick up are Rhinovirus’ which I presume would have a different genetic makeup. But yep if some of the coronovirus ones went in the process, resulting in an overall lower number of colds it would be a result.

ive just experienced my first autumn of having a child go to childcare in September, I’ve had 3 colds so far! Not looking forward to that being the standard for the next 15 years
 
An article in Science magazine details a new method to identify tiny Llama antibodies (nanobodies) that have ultra-high SARS-CoV-2 neutralisation potency and are inhalable, making them much easier to administer.

Key extracts:
... researchers at the University of Pittsburgh School of Medicine describe a new method to extract tiny but extremely powerful SARS-CoV-2 antibody fragments from llamas ...
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Then, with the help of Pitt’s Center for Vaccine Research (CVR), the scientists exposed their nanobodies to live SARS-CoV-2 virus and found that just a fraction of a nanogram could neutralize enough virus to spare a million cells from being infected.
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New method identifies Llama nanobodies with high potency against SARS-CoV-2
 
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Little bit more about the new monoclonal antibody treatment for non-hospitalised patients in the States - (which has been given emergency use authorisation)

“For patients at high risk for disease progression, hospitalisations and emergency room visits occurred in 3% of bamlanivimab treated patients on average compared to 10% in placebo treated patients,” said the agency, and similar effects were seen with all three doses of bamlanivimab.

https://www.bmj.com/content/371/bmj.m4362
 
Another drug showing promise following a trial. More research needed -


“We are pleased to report a 71 percent reduction in mortality for the group receiving baricitinib in addition to standard care,” says Volker Lauschke, corresponding author and associate professor of personalized medicine and drug development at the Department of Physiology and Pharmacology, Karolinska Institutet. “

https://www.cathlabdigest.com/conte...ib-linked-reduced-mortality-covid-19-patients
 
FabioPorkpie said:
Another drug showing promise following a trial. More research needed -


“We are pleased to report a 71 percent reduction in mortality for the group receiving baricitinib in addition to standard care,” says Volker Lauschke, corresponding author and associate professor of personalized medicine and drug development at the Department of Physiology and Pharmacology, Karolinska Institutet. “

https://www.cathlabdigest.com/conte...ib-linked-reduced-mortality-covid-19-patients
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That's 'good news' for over 80s. I wonder how they decide the best treatment for a specific case or whether they can safefully and effectively use multiple treatments.
 
Further estimates that IFRs are reducing,which has to be good news. Hopefully with further treatment advances this will reduce further still, even before vaccination is rolled out successfully.

"Using observations of improved survival in hospitalised COVID-19 patients, we have allowed the probability of dying to given infection (IFR) to gradually change over the course of June 2020, with a decrease being estimated."

https://twitter.com/x/status/1327661504389394433
 
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